Sunday, 13 January 2008

Gene variant raises risk of Chrones disease

At a children's hospital in Philadelphia, Pediatric researchers in a have identified a gene variant that raises the risk of Chrones disease amongst Children.

Some German researchers had also previously found the same gene variant in the adult form of Chrones disease and this new research backs up their findings.

"Because Chrones disease is complex, with multiple genes interacting with each other and with environmental factors, it's important to sort out specific genes and to replicate previous findings," said the study's first author, Robert N. Baldassano, M.D., director of the Center for Pediatric Inflammatory Bowel Disease at Children's Hospital. "There are different types of Chrones disease, so classifying types by genetic profiles may help us select the most appropriate treatments for each patient."

The comprehensive study compared the genomes of One hundred and forty three children with Chrones disease to genomes of 282 children who did not have the disease. In the results, they discovered that Sixty four percent of children with Crohn's disease had a specific variant form of the gene ATG16L1, compared with 52 percent of the healthy children. The odds ratio for children with the gene variant was 1.62 compared to control children, all this means that children who have the variant are 62 percent more likely to have Chrones disease than children with the more common form.

I guess the more studies done like this will all lead to more understanding of Chrones disease and hopefully lead to better treatments and possibly a cure one day.

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