A few Causes and Facts of Chrones Disease

In my post today I have decided to go over a few more of the facts, causes and symptoms of Chrones Disease.

What exactly is Chrones Disease?
Chrones disease is defined as a chronic autoimmune disease which can affect any part of the gastrointestinal tract but most commonly occurs in the ileum, the ileum is the area where your large and small intestines meet.

Chrones Disease are there other names for the disease?
Firstly the correct spelling of Chrones Disease is actually Crohn's Disease, I use Chrones every time im when im not really thinking about it, and have found that so do many other people and so this blog is really for people who like me keep forgetting how to spell it - now it has just stuck! Other names for chrones are: Inflammatory bowel disease, Crohn's disease, Regional enteritis, Ileitis and Granulomatous ileocolitis. Chrones disease is similar to ulcerative colitis but is not the same. (more of the differences between Chrones disease and ulcerative colitis later)

What are the causes of Chrones disease?
Chrones is an autoimmune disease, which means that your immune system attacks your body's own cells. In the Autoimmune disorder in Chrones disease, these 'bad' immune cells attack the gastrointestinal system. The actual cause of why this happens is still not known, but there seems to be some sort of a link to genetics.

In Chrones disease this often happens in the ileum, where the end of the small intestine joins the large intestine. But chrones can also affect any other part of your digestive system. What happens is the wall in your intestines thickens and deep ulcers often occur well as your digestive system chrones disease can also affect other organs in your body and may cause, Skin rash, Fistulas which are abnormal connections between your digestive system and adjacent organs or skin, Liver inflammation, arthritis, your eyes can become inflamed, kidney stones and deep vein thrombosis.

About Chrones Disease - Some Facts

I have had a few queries from people asking what is Chrones Disease? (which is correctly spelt Crohn's disease)

Basically Chrones disease is a chronic and debilitating inflammatory disease of the
gastrointestinal tract that is incurable. Chrones disease usually occurs in people between the ages of 18-25, but can begin much later in life as well.

Because Chrones disease is chronic, patients often go through unpredictable periods in which the disease flares up and the symptoms of the disease re-appear. Then these periods are followed by periods of remission where the symptoms disappear or decrease and the person with chrones appears to be in good health.

Throughout the world, the west has the highest percentage of chrones disease sufferers, with Canada having one of the highest rates in the world.

The cause of Chrones disease is not really known but it is believed to be an autoimmune disease that has links to genetics. The condition occurs when the immune system contributes to damage of the gastrointestinal tract by causing inflammation.

As mentioned earlier, there is currently no known medical or surgical cure for Chrones disease, unlike the other major type of IBD called ulcerative colitis.

Many people live with Chrones disease for many years and dont know that they have it until the usual onset of chrones disease between the ages of 15 and 30. There are no difference in numbers or chances of getting the disease between men and women.

Chrones disease can cause a variety of symptoms that include Growth failure which is common in children who have Chrones disease. Infact many children are first diagnosed with Chrones disease based on inability to maintain normal growth.

Older people who have Chrones disease may show weight loss coupled with decreased food intake, since individuals with intestinal symptoms from Chrons disease often feel better when they do not eat and might lose their appetite. This is often one of the fist signs that a person has Chrones Disease.

Chrones Disease Books

I found that books about Chrones Disease a great help to me when I was first diagnosed, some really helped and some left me with more questions than answers! That is why I thought it's would be a good Idea to create a post about some of the books that are available and then possibly in the future write a sort of Chrones Disease Book review.

Also just to let you know I will try and find links to the books for both USA and UK book sites as well as many other countries that I can find, if any of you are from any other country and know where you can find them online please let me know and I will add them. I have also where possible linked to sites that offer 2nd hand books as this is greener (save the trees!!) and cheaper too :-)

The Chrones Disease and Ulcerative Colitis Fact Book
Taken from the back cover: "Crohn's disease nearly took my life and dream of running in the Olympics. This book is helping me control my disease and stay in training." --Rene Felton, Track and Field National Record Holder"

"This text gave me a better insight into my illness. I have found that knowing what to expect makes coping with the disease easier." --Rolf Benirschke, Placekicker, San Diego Chargers

Where you can buy The Chrones Disease and Ulcerative
Colitis Fact Book:

Amazon USA:

USA: AbeBooks.com Used: $1.00!!

UK: Amazon.co.uk New £10.99
UK: AbeBooks.co.uk Used: £1.00

Australia: AbeBooks New A$27.73

Canada: AbeBooks Used C$10.67

France and Germany: The Chrones Disease and Ulcerative Colitis Fact Book is also available from any of the AbeBooks links above.

Australians with Chrones Disease to get further help

People who suffer with Chrones Disease in Australia are to receive more help
There has been some excellent news for those of you with Chrons disease, an inflammatory bowel condition (IBD) and who are living in Australia as it has been announced that sufferers will be able to receive susidised treatments.

Remicade
Remicade (infliximab) will be added to the Pharmaceutical Benefits Scheme in Ausralia (PBS). The Minister for Health in Australia, said Chrones disease has a huge effect on the professional, family and social life of sufferers and that the Australian Government would do what it could to help.

Chrones Disease Symptoms
The main symptoms include fever, weight loss or even anorexia, tiredness and joint pain. An people with active Chrones disease, sometimes called a flare up often experience chronic abdominal pain, diarrhoea and bowel movements that conain blood.

An expected 2,000 people will probably start on Remicade for the treatment of Chrones disease in Australia in the first year of its listing and this inclusion of Remicade to the PBS will probably cost around $53.9 million Australian Dollars over the next four years.

Chrones Disease Beaten by Diet in Bible

Florida man says that by following scriptures from the bible, he was able to beat Chrones Disease.

Jordan Rubin who now lives in Florida and the author of "The Makers Diet" says that out of the many thousands of diet books being printed every year, the oldest one is the the best. He goes on to say that by eating "whole, living and nutrient-rich foods" that are described in the bible he was able to overcome Chrones disease.

Almost a decade ago the doctors told Jordan that his chrones disease was incurable, but according to him, he has manage to beat his disease after researching the Bible's "4,000-year-old health plan." It must be noted that he has used these ideas to found a health company, Garden of Life Inc.

So has Jordan Rubin rediscovered something that has been missed by modern Western medicine? Or is he just using conventional wisdom by not eating pork and red meat and eating plenty of natural foods?

If you are interested in this form of treatment he has a book as I mentioned earlier that is now for sale and can be bought from many good bookshops. I have also placed a couple of links to Amazon if you are interested:

If you are from the UK:


If you are from the USA:

Chrones Disease Video

I found this video the other day, it is a touching story of a guy with Chrones Disease. The backing music is by Perl Jam - the reason for this and is not something I knew until now is that the Pearl Jam guitarist Mike McCready suffers from Chrones Disease.

He announced this news way back in 2003 and said that he has had the stomach ailment for the past 15 years, so 20 years now. The reason he decided to go public with the news was because of the strength of a young teenager who'd suffered through 6 surgeries because of chrones and still had a long way to go.

During his speech, Mike McCready recountered a particularly embarrassing incident to demonstrate how Chrones can strike at any time. He said that whilst playing onstage, he is always aware of where the bathrooms are "When Crohn's hits, I have to run, or it won't be pretty. It happened when we opened up for the Rolling Stones in 1997 in Oakland .

"It was our first show with them," McCready continues. "Five minutes before we went on, I went up to (Pearl Jam front man) Eddie Vedder and I said, 'Look man, can we play 'Sometimes'? — which is a slower song that I'm not really on. I was in pain. I went running offstage looking for a bathroom, and there wasn't one. Then, all of a sudden, there was one. It was a honey bucket. I heard my band play that song from inside a portable toilet!" something every chrones disease sufferer knows all to well!

Tysabri Approved for Chrones Disease Treatment

People with Chrones Disease have some excellent news in that the US Food and Drug Administration has approved the use of a drug called Tysabri (natalizumab) to treat people with chrones disease who have not yet responded to other forms of treatment.

Tysabri has potentially some pretty serious side effects and because of this people with chrones disease who are using the drug Tysabri will also be enrolled in a program that restricts distribution called Crohn's Disease-Tysabri Outreach Unified Commitment to Health (CD-TOUCH). Some of the possible side effects of Tysabri include anaphylactic reactions,possible liver injury, progressive multifocal leukoencephalopathy (a viral infection that affects the brain. This viral infection could cause severe disability or even death.)

The CD-TOUCH program will allow physicians to check people with chrones disease that are using Tysabri after three months, if there is no sign of improvement Tysabri will no longer be perscribed.

Tysabri was approved way back in 2006 for the treatment of patients suffering from elapsing multiple sclerosis and now has to go ahead to be used on Chrones Disease sufferers. It is produced by Elan, a company based in Ireland as well as Biogen Idec in the US and will used on patients with chrones who have yet to respond to any other forms of treatment


What is Chrones Disease?
Chrones Disease affects the bowel. It is incurable and the symptoms include diarrhea, fever, rectal bleeding, malnutrition, narrowing of the intestines, cramping, and abdominal pain. More than 1 million people around the world have chrones disease.

The disease can also lead to abnormal connections in the gut which are called fistulas these connections grow from the intestines to the skin or internal organs.

Details of the Drug
Drug Name: TYSABRI (Brand Name Drug)
Company: BIOGEN IDEC
FDA Application No. (BLA) 125104
Active Ingredient: NATALIZUMAB
Original Approval or Tentative Approval Date: November 23, 2004